The purpose of this study was to formulate an Orodispersible tablet of Itopride Hydrochloride by direct compression method. It’s unpleasant taste and hence taste masked by ion exchange resin method which rapid onset of action, increased bioavailability and dual mode action of antiemetic and prokinetics. The tablets were made by direct compression method using Kyron T-314, Sodium starch glycolate, Crosscarmellose sodium and crosspovidone as superdisintegrant conc. 0.5%, 1.0% and 1.5% respectively and taste masking using ion exchange resin method kyron T-114 used as a taste masking ratio 1:1 to 1:4 and also by solid dispersion method. Characterization of DRC in which drug content, In vivo taste evaluation, In vitro drug release, drug- polymer interaction study and drug resin complex formation and also evaluations of the formulations were conducted including weight variation, hardness, disintegration time, friability and in-vitro dissolution. The DSC study showed complete disappearance of the Itopride peak confirming complex formation by ion exchange resin method. FTIR study revealed no interaction between drug and polymer. DRC drug: kyron T-114 (1:3) was optimized and the results show that the presence of a superdisintegrant kyron T 314 [0.5%] gives good result. DT 13 sec., drug content of 99.7 % & 98.83±0.9 % drug release within 10 min. and as compared with the conventional tablet (23.43±1.3%). Short term stability study of optimized formulation showed that formulation was stable. Orodispersible tablets of Itopride Hydrochloride with acceptable disintegration time, rapid drug release and good hardness and taste masked.
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